3. Podocyte Injury in Glomerular Diseases
نویسنده
چکیده
Together with glomerular endothelial cells (GEN) and glomerular basement membrane (GBM), podocytes form the glomerular filtration barrier in the kidney (Figure 3.2.). Podocyte damage or loss is an early symptom of many kidney diseases presenting clinically with proteinuria with or without nephrotic syndrome and renal failure owing to glomerulosclerosis. Injury to other components of the glomerular filtration barrier, such as GEN and GBM, may also present with nephrotic syndrome, proteinuria and renal failure, which suggests podocyte injury is not the only cause of those abnormalities.
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